,Structural implications of Dpy30 oligomerization for MLL/SET1 COMPASS H3K4 trimethylation

• 作 者: Hongmei Zhang Mei Li Yu Gao Chenjun Jia Xiaowei Pan Peng Cao Xuelin Zhao
• 机 构: Institute of Biophysics, Chinese Academy of Sciences,Beijing 100101, China“,”University of Chinese A
• 出 处: 蛋白质与细胞
• 发表日期: 2015年2期

Dear Editor,The methylation modifications of histone 3 lysine 4 (H3K4) have essential effects on biological processes including gene expression and transcription,cell cycle progression,and DNA repair.From yeast to mammals,the SET1 and MLL-like (mixed-lineage leukemia) multi-subunit protein complexes,known as SET1 or MLL COMPASS (Schneider et al.,2005),are responsible for H3K4 methylation.