论文部分内容阅读
目的 :旨在研究垂体瘤临床某些特征及常规病理和超微结构改变。 方法 :回顾性研究自 1982年 7月～ 1996年 10月间 4 4 4例经窦蝶手术治疗垂体腺瘤的临床特点 ,其中 119例术中鞍底硬膜取检。光镜检查 4 2 4例 ,免疫组化检查 2 9例 ,电镜检查 10 3例 ,将临床结合病理进行了分析研究。 结果 :发现鞍区非泌乳素垂体腺瘤同样可以产生高泌乳素血症 ;鞍底硬膜有瘤细胞侵犯 78例 (6 5.5% )。 结论 :(1)高泌乳素 (PRL )血症并非泌乳素腺瘤所特有 ,在诊断中应注意鉴别 ;(2 )鞍底硬膜受肿瘤侵犯是垂体腺瘤侵袭邻近组织的一个重要标志 ,与无硬膜侵犯者相比 ,治疗效果有显著差异 ,并和预后密切相关 ;(3)根据病情选择合适的疗法 ,可获得满意效果
Objective: To study the clinical characteristics of pituitary tumors and the pathological and ultrastructural changes. Methods: Retrospective study of the clinical features of 544 sphenoidal sinus surgery for pituitary adenomas from July 1982 to October 1996, of which 119 were performed during the operation. Light microscopy examination of 442 cases, immunohistochemical examination of 29 cases, electron microscopy examination of 103 cases, the clinical combined with pathology was analyzed. RESULTS: It was found that non-prolactinoma pituitary adenomas in the sellar region also produced hyperprolactinemia; and saddle floor dura mater tumor cells invaded 78 cases (6 5.5%). Conclusion: (1) Hyperprolactinemia (PRL) is not specific to prolactinoma, and should be discriminated during diagnosis. (2) Pituitary dural invasion is an important marker of pituitary adenoma invasion in adjacent tissues. Compared with those without epidural invaders, the therapeutic effects are significantly different, and are closely related to the prognosis; (3) According to the condition of the patient to choose the appropriate therapy, can obtain satisfactory results