论文部分内容阅读
巴豆属的各种植物均含许多具有抗溃疡,抗癌和促致癌作用的二萜成分。作者从东非的大果巴豆(Croton megalocarpus)中分离到一种新的稀有的赪桐烷(clerodane)型呋喃二萜类化合物,它具有一个9.10—移—甲基,命名为chiromodine(1)。将粉碎的植物茎皮用石油醚(bp 60～80℃)充分提取48h,蒸去溶剂后的油状残渣在—20℃静置48h,后用乙醚研碎即析出沉淀,继以甲醇反复重结晶得一白色针晶,即为chiromodine。mp 205～206℃,〔a〕_D~(20)—15～o(c,0.39,MeOH)。
The various plants of the genus Croton include many diterpenoids that have anti-ulcer, anti-cancer, and carcinogenic effects. The authors isolated a new rare clerodane-type furan diterpenoid from Croton megalocarpus in East Africa. It has a 9.10-trans-methyl group and is named chiromodine (1). The crushed plant bark was fully extracted with petroleum ether (bp 60-80°C) for 48 hours. The oily residue after evaporation of the solvent was allowed to stand at -20°C for 48 hours, and then the residue was precipitated by trituration with ether, followed by repeated recrystallization from methanol. Get a white needle, that is chiromodine. Mp 205-206°C, [a]_D~(20)-15o(c, 0.39, MeOH).