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肝性脑病指有晚期肝病或作过肝脏门静脉分流术的患者出现的神经精神性综合征。这是病毒性肝炎、药物性或中毒性肝病、妊娠期急性脂肪肝、肝硬变等急慢性肝病的一种并发症。此外,还偶见于先天性氨代谢异常的儿童和那些作过门腔静脉分流术而肝脏本身并无实质性病变的患者。病理学患者大脑中常可见到星形细胞变大、增多及其他非特异性改变。这可能是细胞为适应氨的解毒所需要的代谢活力增强的一种表现,因为在高氨时,星形细胞中同时可见到谷氨酰胺脱氢酶的活力增强。也可能由于血氨代谢旺
Hepatic encephalopathy refers to neuropsychiatric syndrome that occurs in patients with advanced liver disease or with portal vein shunting of the liver. This is a viral hepatitis, drug-induced or toxic liver disease, acute fatty liver during pregnancy, cirrhosis and other acute and chronic liver disease complications. In addition, occasional metamorphosis of children with ammonia metabolism and those who had done ventricle shunt and the liver itself is no substantial disease in patients. Pathological patients often seen in the brain astrocytes larger, more and other non-specific changes. This may be one of the manifestations of increased metabolic activity required by cells to adapt to the detoxification of ammonia, as glutamine dehydrogenase activity is also seen astrocytic in high ammonia. May also be due to blood ammonia metabolism Wang