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为了解新生儿肺炎内源性一氧化氛（NO）和内皮素（ET）的动态变化及其在重症肺炎发病机理中所起的作用，对40例肺炎新生儿进行尿NO2-／NO3-和血浆ET水平的测定。结果示尿NO2-／NO3-在轻症肺炎儿明显升高，而重症肺炎儿却明显下降，随着疾病的恢复，尿NO2-／NO3-相应下降或升高，血浆ET在轻症和重症肺炎儿均高于对照组，病情越重，ET越高，随着疾病恢复，ET水平下降。本研究提示内源性ET合成增加和NO合成不足在重症肺炎乃至呼衰的发病中可能起了重要作用。
In order to understand the dynamic changes of endogenous nitric oxide (NO) and endothelin (ET) in neonatal pneumonia and their roles in the pathogenesis of severe pneumonia, 40 neonates with pneumonia were treated with NO2- / NO3- and Determination of plasma ET levels. The results showed that urinary NO2- / NO3- in children with mild pneumonia was significantly increased, but severe pneumonia was significantly decreased, with the recovery of the disease, the corresponding decline or increase in urinary NO2- / NO3-, plasma ET in mild and severe Pneumonia children were higher than the control group, the more serious the disease, the higher the ET, with the recovery of the disease, ET levels decreased. This study suggests that increased endogenous ET synthesis and NO synthesis may play an important role in the pathogenesis of severe pneumonia and even respiratory failure.