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目前,在医疗上广泛应用着巴比妥类安眠药。考虑到其中尤其是由硫喷妥钠或双乙基巴比妥钠所引起的对机体的安眠作用的快慢呈现着明显的差异,在我们以前的报导中已经指出这主要是由于它们穿透入脑血障壁而到达中枢神经系统脑组织各部位的速度有着显著的区别所引起的,如硫喷妥钠在注入机体后5分钟即能进入深度睡眠,可是由双乙基巴比妥钠所引起的深睡却要在注入后1小时才能达到。基于脑组织中含有丰富的磷结合物,本文的
At present, barbiturates are widely used in medicine. In view of the apparent differences in the hypnotic effects on the body, especially caused by thiopental or bis-ethyl-pentobarbital, it has been reported in our previous reports that this is mainly due to their penetration into There is a significant difference in the speed at which cerebral blood reaches the brain in all parts of the central nervous system. For example, thiopental sodium can enter deep sleep within 5 minutes after being injected into the body, but it is caused by sodium bis-ethyl-pentobarbital The deep sleep but to 1 hour after injection can be achieved. Based on the brain tissue rich in phosphorus conjugates, this article