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AIM:To study estrogen receptor(ER)and estrogen receptormessenger RNA(ERmRNA)expression in gastric carcinomatissues and to investigate their association with the pathologictypes of gastric carcinoma.METHODS:The expression of ER and ERmRNA in gastriccarcinoma tissues(15 males and 15 females,42-70 yearsold)was detected by immunohistochemistry and in situhybridization,respectively.RESULTS:The positive rate of ER(immunohistochemistry)was 33.3%in males and 46.7%in females.In BorrmannⅣ gastric carcinoma ER positive rate was greater than thatin other pathologic types,and in poorly differentiatedadenocarcinoma and signet ring cell carcinoma the positiverates were greater than those in other histological types ofboth males and females(P<0.05).The ER was more highlyexpressed in diffused gastric carcinoma than in non-diffusedgastric carcinoma(P<0.05).The ER positive rate was alsorelated to regional lymph nodes metastases(P<0.05),andwas significantly higher in females above 55 years old,andhigher in males under 55 years old(P<0.05).The ERmRNA(in situ hybridization)positive rate was 73.3%in males and86.7%in females.The ERmRNA positive rates were almostthe same in Borrmann Ⅰ,Ⅱ,Ⅲ and Ⅳ gastric carcinoma(P>0.05).ERmRNA was expressed in all tubularadenocarcinoma,poorly differentiated adenocarcinoma andsignet ring cell carcinoma(P<0.05).The ERmRNA positiverate was related to both regional lymph nodes metastasesand gastric carcinoma growth patterns,and was higher inboth sexes above 55 years old but without statisticalsignificance(P>0.05).The positive rate of ERmRNAexpression by in situ hybridization was higher than that ofER expression by immunohistochemistry(P<0.05).CONCLUSION:ERmRNA expression is related to thepathological behaviors of gastric carcinoma,which mighthelp to predict the prognosis and predict the effectivenessof endocrine therapy for gastric carcinoma.
AIM: To study estrogen receptor (ER) and estrogen receptor messenger RNA (ERmRNA) expression in gastric carcinomatissues and to investigate their association with the pathologictypes of gastric carcinoma. METHODS: The expression of ER and ER mRNA in gastric carcinoma tissues (15 males and 15 females, 42-70 yearsold) was detected by immunohistochemistry and in situ hybridization, respectively .RESULTS: The positive rate of ER (immunohistochemistry) was 33.3% in males and 46.7% in females. Borrmann IV gastric carcinoma ER positive rate was greater than that of other pathologic types , and in poorly differentiated adenocarcinoma and signet ring cell carcinoma the positiverates were greater than those in other histological types ofboth males and females (P <0.05). The ER was more highly expressed in diffused gastric carcinoma than in non-diffused gastric carcinoma (P <0.05) The ER positive rate was alsorelated to regional lymph node metastases (P <0.05), and was significantly higher in females above 55 years old, andhigher in males under 55 years old (P <0.05). The ER mRNA (in situ hybridization) positive rate was 73.3% in males and 86.7% in females. The ER mRNA positive rates were almost the same in Borrmann Ⅰ, Ⅱ, Ⅲ and Ⅳ gastric ER mRNA was expressed in all tubularadenocarcinoma, poorly differentiated adenocarcinoma and signet ring cell carcinoma (P <0.05). The ER mRNA positive rate was related to both regional lymph node metastases and gastric carcinoma growth patterns, and was higher inboth sexes above 55 years old but without statistical significance (P> 0.05). The positive rate of ER mRNA expression by in situ hybridization was higher than that of ER expression by immunohistochemistry (P <0.05). CONCLUSION: ER mRNA expression is related to the pathological behaviors of gastric carcinoma, which mighthelp to predict the prognosis and predict the effectiveness of endocrine therapy for gastric carcinoma.