Loss of heterozygosity for loci on chromosome arms 1p and 10q in oligoden-droglial tumors: relations

• 作 者: Thiessen B Maguire JA McNeil K Huntsman D Martin MA Horsman D
• 机 构: Department of Medical Oncology British Columbia Cancer Agency,Vancouver General Hospital,Vancouver,B
• 出 处: 中国神经肿瘤杂志
• 发表日期: 2003年04期
• 关键词: heterozygosity chromosome prognostic correlate glial typing

Oligodendroglial tumors frequently have deletions ofchromosomal loci on lp and l9q.Loas of heterozygosity(LOH)of chromosome 10 may be a negative prognostic factor.We reviewed 23 patients with oligodendroglial tumors,toevaluate the frequency of lp and 10q LOH and correlate with clinical outcome.Three loci(DlS402,DlSl 172,MCT118)on lp and 2 loci(Dl0S520 and D10S521)on 10q were analyzed for LOH using PCR techniques.Sixteen

Oligodendroglial tumors frequently have deletions of chromosomal loci on lp and l9q. Loas of heterozygosity (LOH) of chromosome 10 may be a negative prognostic factor. We have reviewed 23 patients with oligodendroglial tumors, toevaluate the frequency of lp and 10q LOH and correlate with clinical outcome. Three loci (DlS402, DlSl 172, MCT118) on lp and 2 loci (D10S520 and D10S521) on 10q were analyzed for LOH using PCR techniques. Sixteen