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目的 探讨成人急性白血病的免疫表型特征与诊断价值。方法 采用流式细胞仪对59例成人急性白血病进行免疫表型分析。结果 急性淋巴细胞白血病除均表达淋系抗原外 ,有15.0%伴有髓系抗原(CD13、CD33、CD11b)的表达 ;急性髓细胞白血病均表达髓系抗原 ,同时有13.9%伴有淋系抗原(CD7)的表达。2例细胞形态学不能确定的白血病结合免疫表型分别确诊为M7和HAL;1例形态学诊断为慢粒急淋变的病例 ,经免疫表型检测后诊断为HAL。结论 免疫表型分析能确诊一些特殊类型的白血病 ,在急性白血病的诊断分型及治疗预后中具有重要价值
Objective To investigate the immunophenotypic characteristics and diagnostic value of adult acute leukemia. Methods Fifty-nine adult acute leukemia were analyzed by flow cytometry. Results In addition to lymphoid leukemia, all patients expressed leukemia antigens, and 15.0% had expression of myeloid antigens (CD13, CD33, and CD11b). Acute myeloid leukemia expressed myeloid antigens, and 13.9% had lymphoid antigens. (CD7) expression. Two cases with unidentifiable leukemia-binding immunophenotype were diagnosed as M7 and HAL, respectively; one case was diagnosed as a case of acute granulomatous leukemia, and the diagnosis was HAL after immunophenotyping. Conclusion Immunophenotyping can be used to diagnose some special types of leukemia, which is of great value in the diagnosis and treatment of acute leukemia.