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用免疫细胞化学方法研究了１９～４０周人胎初级视皮质含Ｐａｒｖａｌｂｕｍｉｎ（ＰＶ）神经元及纤维的发育和形态。１９周，少数含ＰＶ神经元出现于皮质板深部（相当于Ⅵ层处）。２４周，含ＰＶ神经元仍仅见于Ⅵ层，但数量明显增加，多为双极细胞。２６～２９周，许多含ＰＶ神经元可见于Ⅵ及Ⅴ层，双级、多级及双簇细胞均可见。３３～４０周，Ⅴ、Ⅵ层含ＰＶ神经元数目逐渐增加，并随胎龄增大依次出现于Ⅳ、Ⅲ和Ⅱ层，多为多极及双簇细胞。这些结果提示，Ⅱ－Ⅵ层含ＰＶ神经元遵循从深至浅的发育规律。另外，２９～４０周皮质Ⅰ层一些Ｃａｊａｌ－Ｒｅｔｚｉｕｓ神经元和水平纤维亦含ＰＶ；３８～４０周皮质Ⅰ层深部还可见较多含ＰＶ的小型神经元，散在分布于Ⅰ层含ＰＶ的水平纤维之间，提示ＰＶ可能参与发育过程中Ⅰ层内各种神经成分间的相互作用。
Immunocytochemistry was used to investigate the development and morphology of Parvalbumin (PV) neurons and fibrils in human primary visual cortex from 19 to 40 weeks. At 19 weeks, a few PV-containing neurons appeared in the cortical plate deep (equivalent to Ⅵ layer). At 24 weeks, PV-containing neurons still only found in layer Ⅵ, but the number increased significantly, mostly bipolar cells. From 26 to 29 weeks, many PV-containing neurons were found in Ⅵ and Ⅴ layers, with double, multiple and double cluster cells visible. From 33 to 40 weeks, the number of PV neurons in Ⅴ and Ⅵ layers gradually increased, and appeared in layers Ⅳ, Ⅲ and Ⅱ with the increase of gestational age, mostly in multipole and double cluster cells. These results suggest that PV neurons in the II-VI layer follow the rule of deep to shallow development. In addition, some Cajal-Retzius neurons and horizontal fibers also contained PV in the cortex I-layer of 29-40 weeks. More small PV-containing neurons were seen in the depths of layer I 38- 40 weeks, Fiber, suggesting that PV may be involved in the development of a variety of nerve components in the interaction between layers.