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本研究观察了使用黄芫花乙醇注射液抗早孕时,孕妇外周血中雌二醇(E_2)、孕酮(P)、前列腺素(PGE_2)、前列腺素F_(2α)(PGF_(2α))含量与蜕膜组织中PGE_2及PGF_(2α)和孕酮受体(PR)含量的变化。结果表明黄芫花乙醇注射液可使蜕膜组织变性、坏死,同时使其PGE_2、PGF_(2α)含量增加,PR含量降低,而外用血中PGE_2、PGF_(2α)含量不变,E_2、P含量减少。提示:黄芫花乙醇注射液抗早孕的主要环节可能是使蜕膜变性、释放前列腺素,从而干扰维持早孕的因素,达到终止妊娠目的。
This study was conducted to observe the levels of estradiol (E_2), progesterone (P), prostaglandin (PGE_2), and prostaglandin F_(2α) (PGF_(2α)) in pregnant women’s peripheral blood when using ethanol injections of astragalus for early pregnancy. Changes of PGE_2, PGF_ (2α) and Progesterone Receptor (PR) in Decidua Tissues. The results showed that ethanol injection of Astragalus could degenerate and necrosis the decidua tissue, increase the PGE 2 and PGF 2a content, and decrease the PR content. However, the content of PGE 2 and PGF 2a in the external blood remained unchanged, and the content of E 2 and P decreased. . The main link of anti-early pregnancy with ethanol injection of Astragalus may be degeneration of the decidua and release of prostaglandins, which may interfere with the maintenance of early pregnancy and achieve the purpose of termination of pregnancy.