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人类胸苷酸合成酶(thymidylate synthase,TS)是DNA合成的关键酶,它在DNA合成与修复过程中发挥重要作用。TS基因的多态性可能影响TS蛋白的表达,从而影响酶的活性及功能,导致个体对癌症易感性的差异,甚至影响癌症患者对化疗的疗效及总体预后。食管癌是我国最常见的六大恶性肿瘤之一,它的确切发病原因目前尚不清楚。近年来,分子
Human thymidylate synthase (TS) is a key enzyme in DNA synthesis and plays an important role in DNA synthesis and repair. TS gene polymorphism may affect TS protein expression, thus affecting enzyme activity and function, leading to individual differences in the susceptibility to cancer, and even affect the cancer patients with chemotherapy and overall prognosis. Esophageal cancer is one of the six most common malignant tumors in our country. The exact cause of esophageal cancer is not yet clear. In recent years, molecules