【摘 要】
：
合成了两亲性壳聚糖衍生物(Chit-DC)和偶联小肠靶向因子VB12的两亲性壳聚糖衍生物(Chit-DC-VB12),检测其生物相容性、负载灯盏花乙素(Scu)后的缓释效果、对Scu生物利用度及对
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合成了两亲性壳聚糖衍生物(Chit-DC)和偶联小肠靶向因子VB12的两亲性壳聚糖衍生物(Chit-DC-VB12),检测其生物相容性、负载灯盏花乙素(Scu)后的缓释效果、对Scu生物利用度及对糖尿病视网膜病变疗效的影响。通过FTIR分析和HNMR谱图分析,证实了Chit-DC和Chit-DC-VB12的合成。CCK-8分析显示Chit-DC和Chit-DC-VB12的毒性较小。发现两种
An amphipathic chitosan derivative (Chit-DC-VB12), which is a derivative of chitosan (Chit-DC) and a conjugate of small intestine-targeting factor VB12, was synthesized and its biocompatibility was tested. Effect of Scu on the sustained release, the bioavailability of Scu and the therapeutic effect on diabetic retinopathy. The synthesis of Chit-DC and Chit-DC-VB12 was confirmed by FTIR analysis and HNMR spectral analysis. CCK-8 analysis showed less toxicity of Chit-DC and Chit-DC-VB12. Found two kinds
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