【摘 要】
：
High-fat diet(HFD)treatment as little as 3 d induced fatty liver,insulin resistance and adipose inflammation.n3 PUFAs and their metabolites eicosanoids mediate
【机 构】
：
Department of Physiology and Pathophysiology,Tianjin Medical University,
论文部分内容阅读
High-fat diet(HFD)treatment as little as 3 d induced fatty liver,insulin resistance and adipose inflammation.n3 PUFAs and their metabolites eicosanoids mediate protective effects on several metabolic disorders.However,the functions of n3 PUFA metabolites are largely unknown.Early in the course of HFD feeding for 4 d,we found significant lipid accumulation in mouse liver which was re-
High-fat diet (HFD) treatment as little as 3 d induced fatty liver, insulin resistance and adipose inflammation. N3 PUFAs and their metabolites eicosanoids mediate protective effects on several metabolic disorders. However, the functions of n3 PUFA metabolites are largely unknown. Early in the course of HFD feeding for 4 d, we found significant lipid accumulation in mouse liver which was re-
其他文献
目的：探讨CIP2A对PP2A的调节及其在阿尔茨海默（ Alzheimer disease，AD）样tau蛋白异常磷酸化中的作用。方法：免疫荧光检测CIP2A表达及定位；Western Blot检测相关蛋白表达。结果：N2a细
目的:通过分析C57BL/6野生型小鼠和TRPV1基因敲除鼠热性惊厥行为学、脑内炎性因子表达变化,探讨TRPV1对热性惊厥发生及复发的致病机制。方法:高热诱导C57BL/6野生型小鼠和TRP
<正>目的:探讨酸中毒诱导大脑皮层GABA能神经元功能损伤的机理。方法:制备小鼠大脑冠状切片,灌流pH为7.35~7.45的人工脑脊液,选择感觉皮层GABA能神经元为正常组,全细胞电流钳
目的:探究成体大鼠骨髓中神经嵴源细胞的获取,及对受损周围神经的修复作用。方法:富集骨髓神经嵴源细胞间充质球,分离单克隆球,检测长期增殖能力和神经嵴标志的表达,检测向施
在AD病人脑内增加神经发生可有效改善认知功能，饮食限制（ DR）能够增加成年哺乳动物脑内的神经发生，而机制不明。为明确饮食限制促进3×Tg－AD小鼠海马DG区神经发生并改善认知功能障
急性缺氧引起大鼠饮水量显著减少,其机制不清楚。穹窿下器(SFO)是与饮水行为有关的脑室周器官,其神经元表达的TRPVs是一种阳离子通道,在调节水电解质平衡中起重要作用。为探
目的:探讨下丘脑腹内侧核(VMH)nesfatin-1对糖尿病(DM)大鼠胃牵张敏感神经元(GD)放电影响及VMH-海马nesfatin-1通路调控。方法:链脲佐霉素腹腔注射制备I型DM大鼠模型,观察nes
目的:研究证实甘丙肽在痛觉信息的传导中起到了一定的抑制作用,但是其具体的作用机制及信号分子通路尚不明确。通过结扎大鼠坐骨神经建立神经痛动物模型,于大鼠伏核分别注射
患者男，17岁，1999-10-20就诊。近两年间发现左侧下颌后牙逐渐倾斜，咀嚼功能下降。检查：为恒牙列，25、35、47未萌出，36牙冠近中倾斜，近中颊尖与34远中邻面相接触，34、36之间无牙冠、残
患者女 ,2 4岁 ,妊娠 2 8周。因下颌后牙进食疼痛就诊。患者进入诊室 ,未及坐稳 ,头即扭向左侧 ,眼球上翻 ,嘴角歪向一侧。数秒后 ,全身肌肉强直 ,两臂曲屈 ,两腿伸直 ,面色