Hyperhomocysteinemia activates aryl hydrocarbon receptor-CD36 pathway to promote hepatic steatosis i

来源 :中国病理生理杂志 | 被引量 : 0次 | 上传用户:HZ8081
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
The current study aims to explore the signaling pathway involved in hyperhomocysteinemia(HHcy)-induced hepatic steatosis.First,we performed a meta-analysis involving 2 057 subjects and revealed that plasma homocysteine(Hcy)levels was associated with an increased risk of nonalcoholic fatty liver disease(P<0.05).Next,C57BL/6 mice were fed a high-methionine diet(HMD)(2%, The current study aims to explore the signaling pathway involved in hyperhomocysteinemia (HHcy) -induced hepatic steatosis. First, we performed a meta-analysis involving 2 057 subjects and revealed that plasma homocysteine ​​(Hcy) levels was associated with an increased risk of nonalcoholic fatty liver disease (P <0.05) .Next, C57BL / 6 mice were fed a high-methionine diet (HMD) (2%
其他文献
目的:探究成体大鼠骨髓中神经嵴源细胞的获取,及对受损周围神经的修复作用。方法:富集骨髓神经嵴源细胞间充质球,分离单克隆球,检测长期增殖能力和神经嵴标志的表达,检测向施
在AD病人脑内增加神经发生可有效改善认知功能,饮食限制( DR)能够增加成年哺乳动物脑内的神经发生,而机制不明。为明确饮食限制促进3×Tg-AD小鼠海马DG区神经发生并改善认知功能障
急性缺氧引起大鼠饮水量显著减少,其机制不清楚。穹窿下器(SFO)是与饮水行为有关的脑室周器官,其神经元表达的TRPVs是一种阳离子通道,在调节水电解质平衡中起重要作用。为探
目的:探讨下丘脑腹内侧核(VMH)nesfatin-1对糖尿病(DM)大鼠胃牵张敏感神经元(GD)放电影响及VMH-海马nesfatin-1通路调控。方法:链脲佐霉素腹腔注射制备I型DM大鼠模型,观察nes
目的:研究证实甘丙肽在痛觉信息的传导中起到了一定的抑制作用,但是其具体的作用机制及信号分子通路尚不明确。通过结扎大鼠坐骨神经建立神经痛动物模型,于大鼠伏核分别注射
患者男,17岁,1999-10-20就诊。近两年间发现左侧下颌后牙逐渐倾斜,咀嚼功能下降。检查:为恒牙列,25、35、47未萌出,36牙冠近中倾斜,近中颊尖与34远中邻面相接触,34、36之间无牙冠、残
患者女 ,2 4岁 ,妊娠 2 8周。因下颌后牙进食疼痛就诊。患者进入诊室 ,未及坐稳 ,头即扭向左侧 ,眼球上翻 ,嘴角歪向一侧。数秒后 ,全身肌肉强直 ,两臂曲屈 ,两腿伸直 ,面色
High-fat diet(HFD)treatment as little as 3 d induced fatty liver,insulin resistance and adipose inflammation.n3 PUFAs and their metabolites eicosanoids mediate
期刊
Exogenous EETs or sE H inhibition offers inhibitory effects on obesity progression,which is associated with reduced adipocyte differentiation and adipogenesis,a
期刊
Hydroxysteroid sulfotransferase 2B1(SULT2B1)sulfates cholesterol and oxysterols.Hepatic oval cells(HOCs),thought to be progenitor cells,can be triggered in chem
期刊