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目的:研究盐酸戊乙奎醚(长托宁)用于小儿扁桃体切除手术时对血压(BP)、心率(HR)、呼吸及唾液分泌的影响。方法:60例行扁桃体切除手术的患者,随机分为3组,术前10min分别静注生理盐水(A组)、阿托品0.01mg/kg(B组)、长托宁0.01mg/kg(C组)。分别测量并记录注药前后BP、HR、脉搏氧饱和度(SpO2)及患者口干程度的视觉模拟评分(VAS)。结果:C组注药后HR较基础值无明显变化(P>0.05);B组注药后HR显著增快(P<0.05);注药后10min和拔管后C组的VAS值比B组无明显差异(P>0.05),术后1hC组的VAS比B组低(P<0.05)。结论:术前静注长托宁0.01mg/kg,可有效减少小儿患者术中及术后口腔、呼吸道分泌物,且不增加HR。
OBJECTIVE: To study the effect of penehyclidine hydrochloride (penehyclidine hydrochloride) on blood pressure (BP), heart rate (HR), respiration and saliva secretion during pediatric tonsillectomy. Methods: Totally 60 patients underwent tonsillectomy were randomly divided into 3 groups: group A received normal saline (group A), atropine 0.01 mg / kg (group B) and penehyclidine 0.01 mg / kg ). The visual analogue scale (VAS) of BP, HR, SpO2 and patient's dry mouth before and after injection were measured and recorded respectively. Results: HR in group C was significantly higher than that in baseline (P> 0.05); HR in group B was significantly increased after injection (P <0.05); VAS in group C 10 min after injection and group B after extubation (P> 0.05). The VAS in 1h after operation was lower than that in B (P <0.05). Conclusions: The preoperative intravenous administration of penehyclidine 0.01mg / kg, which can effectively reduce pediatric patients intraoperative and postoperative oral and respiratory secretions, without increasing HR.