【摘 要】
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Mitochondria are dynamic,double-membrane-bound organelle of eukaryotic cells that have evolved to function in a wide range of cellular processes.They are respon
【机 构】
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Learning Key Laboratory for Pharmacoproteomics, Institute of Pharmacy and Pharmacology, Hunan Provin
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Mitochondria are dynamic,double-membrane-bound organelle of eukaryotic cells that have evolved to function in a wide range of cellular processes.They are responsible for oxidative phosphorylation (OXPHOS),producing energy and metabolites,regulating apoptosis and maintaining cell viability.To properly perform these functions,mitochondria depend on hundreds of proteins which are encoded in the nucleus,synthesized in the cytosol,and imported into the organelle.The transport of mitochondrial preproteins is mainly mediated by the translocase of the outer mitochondrial membrane and the translocase of the inner mitochondrial membrane [1].Given the dependence of mitochondrial function on cytosolic synthesized proteins,maintaining efficient mitochondrial protein import is indispensable for cellular and organismal health.Therefore,it is not surprising that some sophisticated protective responses must exist to defend against deficient mitochondrial protein import in cells.
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