【摘 要】
：
Human protein kinase X (PrKX) is an X chromosomeencoded cAMP-dependent protein kinase.PrKX has 50.2％,50.8％,and 44.83％ identity with the catalytic,C-subunit of PKA
【机 构】
：
Institute of Biological Sciences and Biotechnology, Donghua University, Shanghai 201620, China“,”Key
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Human protein kinase X (PrKX) is an X chromosomeencoded cAMP-dependent protein kinase.PrKX has 50.2％,50.8％,and 44.83％ identity with the catalytic,C-subunit of PKAα,PKAβ,and PKAγ,respectively [1].PrKX shares some biochemical characteristics with PKA.Both kinases catalyze phosphorylation of histone H1 and the PKA synthetic septapeptide substrate,referred to as Kemptide (LRRASLG),in vitro.However,the specific activities of PrKX phosphorylation of histone H1 and Kemptide are significantly lower than that of PKA [2,3].
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