卡铂/顺铂和5 Fu/CF联合治疗晚期食道癌

• 作 者: 熊福星 卢昭 史清明
• 机 构: 安徽医科大学第一附属医院肿瘤内科,安徽省结核病医院
• 出 处: 安徽医科大学学报
• 发表日期: 1997年04期
• 关键词: 晚期食道癌 Fu/CF 治疗应用 食道肿瘤 氟脲嘧啶 毒性反应 药物疗法 抗肿瘤药 纵隔淋巴结转移 肾毒性

应用卡铂／顺铂＋５Ｆｕ／ＣＦ治疗晚期食道癌３６例。卡铂、顺铂分别为２００ｍｇ·ｍ－２、３０ｍｇ·ｍ－２，静脉点滴４６ｈ，第一天；５Ｆｕ３７５ｍｇ·ｍ－２·ｄ－１＋ＣＦ２０ｍｇ·ｍ－２·ｄ－１，持续静脉点滴１２０ｈ。此方案２８天重复，共２６次。结果：ＣＲ２例，ＰＲ１６例，ＣＲ＋ＰＲ１８例，有效率５０％，其中初治有效率５３８％。毒性反应有恶心呕吐（Ⅲ度１例），ＷＢＣ下降（Ⅲ度１例），肾毒性轻微，其它毒性反应均为ⅠⅡ级。我们认为，本方案近期疗效好，毒性小，经济实用，值得临床应用。

Carboplatin/cisplatin+5Fu/CF was used to treat 36 cases of advanced esophageal cancer. Carboplatin and cisplatin were 200 mg·m-2 and 30 mg·m-2, respectively, and were intravenously dripped for 46 hours on the first day; 5Fu375mg·m-2·d-1+CF20mg·m-2·d-1, and continuous intravenous drip for 120h. This program is repeated 28 days, a total of 26 times. Results: CR2 cases, PR16 cases, CR+PR18 cases, 50% efficiency, of which initial treatment efficiency 53.8%. The toxicity was nausea and vomiting (1 case of III degree), WBC decrease (1 case of III degree), nephrotoxicity was mild, and other toxicities were grade III. We believe that the short-term curative effect, low toxicity, economical and practical use of this protocol are worthy of clinical application.