胃癌患者血清表皮生长因子的变化

• 作 者: 李炳琳 朱瑞龙 沈伟忠 陈士葆 沈健伟 沈云芳
• 机 构: 上海市宝山区罗店医院内科,第二军医大学长征医院消化内科
• 出 处: 新消化病学杂志
• 发表日期: 1997年12期
• 关键词: 胃癌患者血清 表皮生长因子 尿抑胃素 胃肿瘤 慢性胃炎患者 浸润范围 胃癌细胞 差异无显著性 胃体部 晚期病例

目的探讨人血清表皮生长因子（ｈＥＧＦ）水平与胃癌的关系．方法胃癌患者３３例，男３０例，女３例，年龄３５岁～８１岁，平均６４９岁；慢性胃炎患者３８例，男２５例，女１３例，年龄１８岁～７５岁，平均４３２岁；正常人２０例，男１０例，女１０例．应用ＲＩＡ法检测血清中的ｈＥＧＦ．结果胃癌组血清ｈＥＧＦ（μｇ／Ｌ）为１３５±０６７，正常对照组为０９０±０３３，统计学差异非常显著（ｔ＝２８２５，Ｐ＜００１），慢性胃炎组血清ｈＥＧＦ为０８６±０３３，与正常对照组比较差异无显著性（ｔ＝０４１，Ｐ＞００５）．结论胃癌患者血清ｈＥＧＦ水平升高可能与胃癌发生密切相关．

Objective To investigate the relationship between human serum epidermal growth factor (hEGF) levels and gastric cancer. Methods Thirty-three patients with gastric cancer included 30 males and 3 females, aged 35 to 81 years old, with an average of 64  9 years old; 38 patients with chronic gastritis, 25 males and 13 females, aged 18 to 75 years old, average 43  2 years old; normal 20 cases, 10 males and 10 females. Detection of hEGF in serum by RIA. Results The serum hEGF (μg/L) was 135±067 in the gastric cancer group and 090±033 in the normal control group. The statistical difference was significant (t=2825, P<001). The serum hEGF of chronic gastritis group was 086±033. There was no significant difference from the normal control group (t=041, P>005). 2. Conclusions The increase of serum hEGF levels in gastric cancer patients may be closely related to the occurrence of gastric cancer.