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为了解糖皮质激素对免疫功能的作用，检测了哮喘发作期患儿。对经丙酸倍氯松（ＢＤＰ）吸入治疗的患儿及正常儿童外周血淋巴细胞膜ＩＬ－２受体（ｍＩＬ－２Ｒ）、超微结构、血浆游离ＩＬ－２受体（ｓＩＬ－２Ｒ）、淋巴细胞亚群及ＢＤＰ对体外培养淋巴细胞ｍＩＬ－２Ｒ的表达进行比较。结果显示，ＢＤＰ可以明显抑制ＰＨＡ刺激引起的体外培养淋巴细胞ｍＩＬ－２Ｒ的表达，引起淋巴细胞的凋亡，而吸入ＢＤＰ（２００μｇ／ｄ）的哮喘患儿（缓解期）除ｓＩＬ－２Ｒ比哮喘发作期显著降低（Ｐ＜０．０５）外，外周血淋巴细胞ｍＩＬ－２Ｒ及淋巴细胞亚群并未出现显著变化．结果提示，抑制淋巴细胞ｍＩＬ－２Ｒ表达和淋巴细胞活化可能是ＢＤＰ治疗哮喘等变态反应的重要机制之一。吸入ＢＤＰ主要是呼吸道局部作用，对全身细胞免疫指标影响不大
To understand the effect of glucocorticoids on immune function, children with asthma attack were tested. The levels of IL-2R, ultrastructure, plasma IL-2 receptor (sIL-2R), interleukin-2 receptor (IL-2R) in peripheral blood lymphocytes of children and normal children treated with beclomethasone propionate (BDP) Lymphocyte subsets and BDP were compared to the expression of mIL-2R in cultured lymphocytes in vitro. The results showed that BDP could significantly inhibit the expression of mIL-2R induced by PHA in vitro and induce the apoptosis of lymphocytes, while those with inhaled BDP (200μg / d) (sIL-2R) There was no significant change in the levels of mIL-2R and lymphocyte subsets in peripheral blood lymphocytes except the onset time (P <0.05). The results suggest that inhibition of lymphocyte mIL-2R expression and lymphocyte activation may be BDP treatment of allergic asthma and other important mechanisms. Inhalation of BDP mainly respiratory local effects, little effect on systemic immune indicators