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研究用红细胞（ＲＢＣ）作为超氧化物歧化酶（ＳＯＤ）载体的可行性，将包载ＳＯＤ的ＲＢＣ（ＲＢＣ－ＳＯＤ）用于家兔脑缺血－再灌注（Ｉ－Ｒ）模型研究。采用５１Ｃｒ标记测量ＲＢＣ的循环半寿期（ ），兔自身ＲＢＣ的，ＲＢＣ－ＳＯＤ的ＲＢＣ－ＳＯＤ对脑Ｉ－Ｒ期间脂质过氧化物（ＬＰＯ）的升高有一定程度的抑制作用。对照组再灌１０ｍｉｎ时，血浆一氧化氮（ＮＯ）浓度达最高；对照组和游离ＳＯＤ组从缺血１０ｍｉｎ到再灌２７０ｍｉｎ，ＮＯ浓度逐渐回落；但ＲＢＣ－ＳＯＤ组在２７０ｍｉｎ的再灌期间，ＮＯ始终处于持续较高浓度状态。提示完整的ＲＢＣ－ＳＯＤ载体能够清除脑Ｉ－Ｒ时产生的超氧阴离子自由基（ ）。
To study the feasibility of using red blood cells (RBCs) as a superoxide dismutase (SOD) carrier, RBC-SOD containing RBCs was used in rabbit models of cerebral ischemia-reperfusion (I-R). RBC circulating half-life (RBC), RBC-RBC RBC-SOD (RBC-SOD), and RBC-SOD of RBC-SOD were measured to inhibit the increase of LPO to a certain extent. In the control group and the free SOD group, the concentration of nitric oxide (NO) in the control group and the free SOD group decreased gradually from 10 min to 270 min after reperfusion, while the NO concentration gradually decreased. However, during the 270 min reperfusion period, NO is always at a higher concentration. It is suggested that the intact RBC-SOD vector can clear the superoxide anion radical () produced by brain I-R.