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近二十年来,免疫学的迅速发展为疾病的防治及病理研究开辟了新的领域,妊娠中毒症至今是一个病因不明的疾病。虽然认为本病与免疫有关可以追溯到本世纪初,但只是在近年内才引起人们的重视。本文综述近年来国内外有关文献,从胎儿为什么不被母体免疫系统排斥着手讨论几个问题,以为今后对该病发病机理研究提供线索。一、胎儿为什么不被排斥由于胎儿的一半基因来自父系,这就意味着妊娠时母体要接触异体“非己”组织抗原。人体最基本的免疫功能在于识别和排斥“非己”物质。业已证明哺乳类动物免疫系
In the recent two decades, the rapid development of immunology has opened up new fields for the prevention and treatment of diseases. Gestational poisoning is by now a disease of unknown etiology. Although the disease is thought to be related to immunity dating back to the beginning of this century, it has only attracted people’s attention in recent years. This article summarizes the recent literature both at home and abroad, from the fetus why not be excluded from the maternal immune system to discuss several issues, in order to provide clues to the pathogenesis of the disease in the future. First, why the fetus is not excluded Because half of the fetus gene from the paternal, which means that the mother to be pregnant during pregnancy to contact allogeneic non-tissue antigen. The most basic immune function of the human body is to identify and exclude “non-self” substances. The mammalian immune system has been demonstrated