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目的:探讨乌司他丁对重型颅脑损伤(SCCI)对患者脑氧代谢、炎性因子及肾功能的影响。方法:将98例SCCI患者随机分为对照组和观察组,每组患者49例。对照组患者给予常规对症支持治疗,观察组患者在此基础上给予乌司他丁滴注治疗。比较两组治疗前及治疗第3 d、7 d的脑氧代谢(SjvO_2、CaO_2、A-vDO_2和CERO_2)、炎性因子(TNF-α、IL-6和IL-10)及肾功能(BUN和Cr)的变化。结果:治疗前,两组患者的SjvO_2、CaO_2、A-vDO_2、CERO_2、TNF-α、IL-6、IL-10、BUN和Cr水平比较差异均无统计学意义(P>0.05);治疗3 d、7 d,观察组患者的SjvO_2、CaO_2和IL-10水平均显著高于对照组,A-vDO_2、CERO_2、TNF-α、IL-6、BUN和Cr水平均显著低于对照组,差异显著具统计学意义(P<0.05)。结论:乌司他丁治疗SCCI可有效改善患者的脑氧代谢、肾功能,减轻炎症反应。
Objective: To investigate the effect of ulinastatin on cerebral oxygen metabolism, inflammatory factors and renal function in patients with severe craniocerebral injury (SCCI). Methods: 98 patients with SCCI were randomly divided into control group and observation group, 49 cases in each group. Patients in the control group were given conventional symptomatic and supportive treatment, and patients in the observation group were given ulinastatin infusion on the basis of this. The cerebral oxygen metabolism (SjvO_2, CaO_2, A-vDO_2 and CERO_2), inflammatory cytokines (TNF-α, IL-6 and IL-10) and renal function (BUN And Cr) changes. Results: Before treatment, there was no significant difference in the levels of SjvO_2, CaO_2, A-vDO_2, CERO_2, TNF-α, IL-6, IL-10, BUN and Cr between the two groups (P> 0.05) d, and 7 d, the levels of SjvO_2, CaO_2 and IL-10 in the observation group were significantly higher than those in the control group, and the levels of A-vDO_2, CERO_2, TNF-α, IL-6, BUN and Cr in the observation group were significantly lower than those in the control group Significantly statistically significant (P <0.05). Conclusion: Ulinastatin can improve cerebral oxygen metabolism, renal function and reduce inflammatory reaction in patients with SCCI.