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本文对25例急性心肌梗塞(AMI)患者血浆环磷酸腺苷(cAMP)、环磷酸鸟苷(cGMP)与心肌酶谱的动态变化相关性研究。同时设正常对照30例。结果:患者于入院时和入院后 8、6、24、48、72小时和 7天分别测试的 cAMP、CGMP含量均呈水平降低直到逐渐恢复。与正常对照比较 P<0.01。在同样时间测心肌酶谱:AST、CK、LDL、HBDH均明显升高与对照组比较有显著性差异。CAMP、cGMP与心肌酶谱均有相关性。但cAMP与心肌酶入院时和入院后8、16、48小时相关性最明显 P<0.05—0.01。cGMP与心肌酶入院后 8、16、48小时相关性最显著P<0.01—0.05。提示血浆核苷酸水平在AMI时可作为一项重要的检测指示,有助于预测心功能、心律失常、梗塞面积大小及预后等。
In this paper, 25 patients with acute myocardial infarction (AMI) in patients with plasma cyclic AMP, cGMP and myocardial enzymes dynamic changes correlation study. At the same time set the normal control in 30 cases. Results: The levels of cAMP and CGMP in patients on admission and at 8th, 6th, 24th, 48th, 72th, 72th and 72th days after admission were decreased until they gradually recovered. Compared with the normal control, P <0.01. In the same time myocardial enzyme spectrum: AST, CK, LDL, HBDH were significantly higher than the control group were significantly different. CAMP, cGMP and myocardial enzymes were related. However, the correlation between cAMP and myocardial enzyme 8 and 48 hours after admission was the most significant P <0.05-0.01. The correlation between cGMP and myocardial enzyme 8,16,48 hours after admission was the most significant P <0.01-0.05. It is suggested that plasma nucleotide level can be used as an important detection indicator at AMI to predict cardiac function, cardiac arrhythmia, infarct size and prognosis.