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在调节休止期淋巴细胞扩增和成熟,从而在免疫反应中表达其特殊功能中,T细胞在抗原刺激下产生的生长和分化因子十分重要。其中,白细胞介素2(IL-2)在调节T细胞生长中占有中心的位置。T细胞的增殖依赖于细胞表面IL-2受体的表达,以及与T细胞分泌的IL-2相互作用。已经知道,IL-2受体的表达和IL-2的分泌,系T细胞抗原受体在抗原/Ia刺激下,或单克隆抗体对T细胞抗原受体Ti/T_3复合物的刺激,或T细胞在促丝裂原刺激下而诱导的。
In regulating the expansion and maturation of lymphocytes in the quiescent state, it is important that T cells produce growth and differentiation factors that are stimulated by the antigen in the expression of their specific functions in the immune response. Among them, interleukin 2 (IL-2) plays a central role in regulating T cell growth. The proliferation of T cells depends on the expression of IL-2 receptors on the cell surface as well as on IL-2 secreted by T cells. It is known that IL-2 receptor expression and secretion of IL-2 are stimulated by T cell antigen receptors under antigen / Ia stimulation or stimulation of the T cell antigen receptor Ti / T_3 complex by monoclonal antibodies or T Cells are induced by mitogen stimulation.