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目的:观察丹参注射液联合注射用还原型谷胱甘肽治疗脑梗死的临床疗效。方法:选取200例脑梗死患者为研究对象,随机分为对照组与观察组各100例。对照组采用注射用还原型谷胱甘肽治疗,观察组在使用注射用还原型谷胱甘肽的基础上联合丹参注射液治疗。观察2组临床疗效,以及治疗前后的美国国立卫生研究院卒中量表(NIHSS)评分、巴塞尔(Barthel)指数,红细胞沉降率(ESR)、红细胞比积(PCV)、纤维蛋白原(FIB)和血浆黏度(ηb)等血液流变学指标。结果:观察组的治疗总有效率为91.0%,高于对照组的71.0%(P<0.05);2组治疗后的NIHSS评分均降低(P<0.05),Barthel指数均升高(P<0.05),观察组NIHSS评分及Barthel指数改善情况均优于对照组(P<0.05);治疗后,2组的ESR、PCV、FIB和ηb均较治疗前降低(P<0.05),观察组血液流变学各项指标的改善程度均优于对照组(P<0.05)。结论:丹参注射液联合注射用还原型谷胱甘肽能改善脑梗死患者的神经功能和日常生活能力,安全有效,值得临床应用推广。
Objective: To observe the clinical efficacy of Danshen injection combined with reduced glutathione in the treatment of cerebral infarction. Methods: 200 patients with cerebral infarction were selected as study object and randomly divided into control group and observation group with 100 cases each. The control group was treated with glutathione for injection. The observation group was treated with Salvia miltiorrhiza injection on the basis of reducing glutathione for injection. The clinical efficacy, NIHSS score, Barthel index, erythrocyte sedimentation rate (ESR), hematocrit (PCV), fibrinogen (FIB) And plasma viscosity (ηb) and other indicators of hemorheology. Results: The total effective rate of the observation group was 91.0%, which was higher than that of the control group (71.0%, P <0.05). The NIHSS scores of the two groups were decreased (P <0.05) ), NIHSS score and Barthel index in the observation group were better than those in the control group (P <0.05). After treatment, the ESR, PCV, FIB and ηb of the two groups were lower than those before treatment (P <0.05) The improvement of various indicators of change is better than the control group (P <0.05). Conclusion: Salvia miltiorrhiza injection combined with reduced glutathione can improve neurological function and daily living ability of patients with cerebral infarction, which is safe and effective. It is worth to be popularized clinically.