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因细菌感染而引起的尿路结石,常表现为鹿角形肾结石或膀胱结石。外科手术治疗这种结石不合算,因为即使由有经验的外科医生施行手术,这种感染性结石的残留率亦高达5%,而且复发率在3年后为17%,15年后达70～80%。这是细菌的尿素酶引起尿素水解,病理性地增加尿中的氨、重碳酸盐和碳酸盐,使尿硷化,从而促进了磷酸铵镁和磷灰石性尿石的形成,同时也增加了细菌的毒力。醋酸羟肟酸的分子结构CH_3-C-NHOH与尿素的结构NH_2-CO-NH_2相近,是一种尿素酶抑制剂,毒性小,不致癌,仅在大剂量时偶可引起畸胎。口服后迅速从肠道吸收,并从肾排出,它抑制尿
Urinary tract stones caused by bacterial infections often manifest as antler-shaped kidney stones or bladder stones. Surgical treatment of such stones is uneconomical because the residual rate of this infectious stone is as high as 5% even with surgery performed by an experienced surgeon and the recurrence rate is 17% after 3 years and 70 ~ 80%. This is a bacterial urease that causes urea hydrolysis, pathologically increases ammonia, bicarbonate and carbonate in the urine, alkalizes urine, thereby promoting the formation of ammonium magnesium phosphate and apatite uroliths, and at the same time It also increases the virulence of bacteria. Acetic acid hydroxamic acid molecular structure CH_3-C-NHOH and urea structure NH_2-CO-NH_2 similar, is a urease inhibitor, less toxic, not carcinogenic, even at high doses can cause teratogenic. After oral administration quickly absorbed from the intestine and excreted from the kidneys, it inhibits urine