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子痫前期是妊娠特有的疾病，由于该病对母儿的危害极大，其发病机制一直是产科研究的焦点。随着研究的不断深入，目前认为该病主要与遗传、血管内皮受损、免疫失衡及炎性反应等因素相关，其中遗传因素是内因，血管内皮损伤因子水平异常升高、血管内皮保护因子水平降低是该病发生、发展的关键环节，而免疫失衡及炎症反应进一步加重血管内皮的损伤，多种机制相互作用导致子痫前期的发生。“,”Preeclampsia is a specific disease of pregnancy, due to its huge harm on mothers and fe-tus,the pathogenesis of the disease have long been the focus of obstetric .Along with the deepening re-search of this disease,the major causes are heredity,vascular endothelium injuries, immune imbalances and inflammatory reaction.Among all these factors, hereditary factor is the internal cause,vascular endo-thelium damage factors abnormity rised and protectins decrease are the key steps of disease development , immune imbalances and inflammatory reaction further aggravate the vascular endothelium injuries , multi-ple mechanism lead to de diseases.