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microRNA（miRNA）是一类普遍存在的小分子RNA，通常在转录后水平抑制靶基因的表达。 miRNA参与了多种疾病的基因调控并与糖尿病病程的发展有关。糖尿病是最常见的内分泌代谢疾病，糖尿病前期是指一种异常的血糖状态，特征为糖耐量减低和（或）空腹血糖受损。糖尿病前期在最终进展为显性2型糖尿病之前，可以持续相当长的时间，目前关于循环miRNA在2型糖尿病及糖尿病前期中的作用仍需大量研究证实。“,”MicroRNAs ( miRNAs) are a family of small nonprotein-coding RNAs.They inhibit the expression of target gene at post-transcriptional level.MiRNAs are involved in gene regulation of various diseases and related on the diabetes development .Diabetes is the most common endocrine met-abolic disease.Pre-diabetes refers to a state of abnormal blood glucose, characteristics of reduce glu-cose tolerance and/or impaired fasting glucose.Pre-diabetes, before eventually developed to overt type 2 diabetes can last a long time.But more studies based on large population are needed to identify the role of circulating miRNA in the type 2 diabetes and pre-diabetes.