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糖尿病肾病（DN）是2型糖尿病患者最常见的微血管并发症之一，也是导致终末期肾病的主要原因。现已认识到肥胖与2型糖尿病的发病显著相关。肥胖与糖尿病一样，是一种多因素、多基因性疾病，与生活方式密切相关。多种类型的肥胖中以腹型肥胖与糖尿病的发生关系最为密切。肥胖患者常伴有胰岛素抵抗，而后者是 DN发生的始动因素。肥胖可促使多种脂肪因子、炎症因子的产生，通过多种机制影响糖尿病肾脏的病理生理及脂质代谢，促使DN的发生。“,”Diabetic nephropathy ( DN) is one of the most common microvascular complications in pa-tients with type 2 diabetes and the main reason of leading to the end-stage renal disease .Now the common view is that obesity is significantly associated with the onset of type 2 diabetes.Just as diabetes,obesity is a kind of multiple factors and polygenic disorder ,which is closely associated with lifestyle .Among various types of obesity,Abdominal obesity is most closely related to the occurrence of diabetes .Obese patients are always accompanied with insulin resistance,while the latter is the initiating factor to diabetic nephropathy occurs .O-besity may accelerate the production of various fat factors and inflammatory markers .They through a variety of mechanisms affect diabetic kidney pathological physiology and lipid metabolism ,prompting the occurrence of diabetic nephropathy.