论文部分内容阅读
目的制备氯雷他定温敏型鼻用凝胶并考察其质量。方法采用包合技术制备氯雷他定和羟丙基-β-环糊精包合物,再与不同配方的泊洛沙姆、卡波姆制成温敏型鼻用凝胶,考察凝胶的胶凝温度、胶凝时间和黏附力等指标,优选基质处方。结果制备得到的包合物载药量为20.15%,包合率为82.07%,鼻用凝胶基质为190 g·L-1泊洛沙姆407和1.0 g·L-1卡波姆,其胶凝温度为32.4℃,黏附力61.5 g·cm-2。结论本方法选定的包合物和基质处方适用于氯雷他定温敏型鼻用凝胶的制备。
Objective To prepare loratadine thermosensitive nasal gel and investigate its quality. Methods Inclusion technique was used to prepare the inclusion compound of loratadine and hydroxypropyl-β-cyclodextrin, and then the poloxamer and carbomer with different formulations were made into temperature-sensitive nasal gel. The gel The gel temperature, gel time and adhesion and other indicators, preferably matrix prescription. Results The content of inclusion compound was 20.15%, the inclusion rate was 82.07%, the gel matrix of nasal gel was 190 g · L-1 poloxamer 407 and 1.0 g · L-1 carbomer, The gelation temperature is 32.4 ℃ and the adhesion is 61.5 g · cm-2. Conclusion The inclusion complex and matrix prescriptions selected by this method are suitable for the preparation of loratadine thermosensitive nasal gel.