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目的 探讨充血性心力衰竭 (CHF)患者血浆中趋化因子水平与心衰病情之间的关系。方法 分别采用酶联免疫吸附法及放免法测定 62例CHF患者 (NYHA分级为II～IV)血浆中单核细胞趋化蛋白 -1(MCP -1)及白细胞介素 -8(IL -8)的浓度。结果 CHF组血浆中MCP -1及IL -8水平较正常对照组明显升高 (P <0 0 1) ,且随心功能分级增加逐步升高 ,与心衰病因无关。血浆中MCP -1水平与左室射血分数、6分钟步行距离、生活质量评分呈显著负相关 (r=-0 42 2 ,-0 2 92 ,-0 42 1,P均 <0 0 5 ) ,与左室舒张末期直径呈显著正相关 (r =0 2 63 ,P <0 0 5 ) ,而IL -8仅与生活质量评分呈显著负相关 (r =-0 42 9,P <0 0 1)。结论 心衰时机体外周血浆中MCP -1及IL -8水平的升高是心衰时机体免疫激活的一个标志 ,也可以作为放映心衰病情的一个新型指标
Objective To investigate the relationship between plasma levels of chemokines and heart failure in patients with congestive heart failure (CHF). Methods The levels of monocyte chemotactic protein - 1 (MCP - 1) and interleukin - 8 (IL - 8) in 62 patients with CHF (NYHA class II to IV) were determined by enzyme - linked immunosorbent assay concentration. Results The levels of MCP - 1 and IL - 8 in CHF group were significantly higher than those in normal control group (P <0.01). The levels of MCP - 1 and IL - 8 increased gradually with the increase of cardiac function grade, which was not related to the cause of heart failure. Plasma MCP-1 levels were significantly negatively correlated with left ventricular ejection fraction, 6-minute walking distance, and quality of life scores (r = -0.242, -0.292, -0.421, all P <0.05) , Positively correlated with left ventricular end-diastolic diameter (r = 0 2 63, P 0 05), while IL -8 was negatively correlated with quality of life score only (r = -0 42 9, P 0 0 0 1). Conclusions The increase of MCP-1 and IL-8 levels in peripheral plasma of patients with heart failure is a sign of immune activation during heart failure and may be used as a new indicator of heart failure