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目的:探讨间断蓝光照射联合枯草杆菌二联活菌颗粒(妈咪爱)及茵栀黄口服液治疗新生儿黄疸的临床疗效。方法:选取我院2012年2月到2014年12月收治的69例采用间断蓝光照射联合枯草杆菌二联活菌颗粒及茵栀黄口服液治疗的新生儿黄疸患儿的临床资料,将其设为研究组,选取同期只采用间断蓝光照射治疗的62例患儿资料,将其设置为对照组,比较两组患儿的临床治疗效果及其治疗前后血清胆红素水平变化。结果:研究组总有效率为89.9%,对照组总有效率为72.6%,两组比较差异有统计学意义(P<0.05);治疗3 d后研究组血清胆红素水平下降明显优于对照组,两组比较差异有统计学意义(P<0.05);研究组不良反应发生率为2.9%,对照组为4.4%,两组比较差异无统计学意义(P>0.05)。结论:间断蓝光照射联合枯草杆菌二联活菌颗粒、茵栀黄口服液治疗新生儿黄疸效果显著,可有效降低患儿的血清胆红素浓度,值得临床推广。
Objective: To investigate the clinical curative effect of intermittent blue light irradiation combined with Bacillus subtilis Erlianbi granules (Mommy Love) and Yinzhihuang Oral Liquid in neonatal jaundice. Methods: The clinical data of 69 neonates with jaundice treated with intermittent blue light irradiation combined with Bacillus subtilis and Moxibacterium spp. And Yinzhihuang oral solution were selected from February 2012 to December 2014 in our hospital. For the study group, we selected 62 children treated with intermittent blue light irradiation during the same period as the control group, and compared the clinical efficacy and serum bilirubin levels before and after treatment in both groups. Results: The total effective rate was 89.9% in the study group and 72.6% in the control group, with a significant difference between the two groups (P <0.05). After 3 days of treatment, the serum bilirubin level in the study group was significantly lower than that in the control group Group, the difference between the two groups was statistically significant (P <0.05). The incidence of adverse reactions in the study group was 2.9% and in the control group was 4.4%. There was no significant difference between the two groups (P> 0.05). Conclusion: Intermittent blue light irradiation combined with Bacillus subtilis two live bacteria particles, Yinzhihuang oral solution treatment of neonatal jaundice significant effect, can effectively reduce the serum bilirubin concentrations in children, worthy of clinical promotion.