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1979年至1883年间诱导缓解的急粒患者67例,年龄≥15岁。诱导方案TAD,即:6-硫鸟嘌呤100mg/M~2/天口服;阿糖胞苷100mg/M~1/12小时静注,共7天;柔毛霉素60mg/M~2/天第5、6、7天。以上方可案重复3个疗程,直到缓解。年龄在15—45岁的患者,若有HLA相同的同胞兄弟,则进行骨髓移植。预处理方案包括:环磷酰胺60mg/kg/天,共2天;全身照射,单次照射者总量为10Gy,分次照射者总量为11.25Gy。照射后当天输注骨髓有核细胞1—4×10~3/公斤体重。预防GVHD只用MTX,不用环胞素,亦不在体外剔除供体骨髓中的T细胞。巩固化疗共用2疗程,第一疗程用杂氮胞苷150mg/M~2/天,共5天;60mg/M~2,第4、5天。第二疗程用原诱导缓解方案。巩固治疗后不再进行维持治疗。移植组23例中,
Between 1979 and 1883, 67 patients with acute granule induction were relieved, aged ≥15 years. Induction program TAD, namely: 6-thioguanine 100mg/M~2/day oral; Cytarabine 100mg/M~1/12 hours intravenously, total 7 days; Robustomycin 60mg/M~2/day Days 5, 6, and 7. The above can be repeated for 3 courses until remission. Patients with 15-45 years of age who have HLA-identical siblings undergo bone marrow transplantation. The pretreatment program included: Cyclophosphamide 60 mg/kg/day for 2 days; total body irradiation, single shot total 10 Gy, and fractional exposure total 11.25 Gy. On the day after irradiation, bone marrow nucleated cells were 1-4×10 3/kg body weight. To prevent GVHD using only MTX, no cyclosporine, and no T cells in donor bone marrow were removed in vitro. Consolidation of chemotherapy with 2 courses, the first course of treatment with azacytidine 150mg/M ~ 2 days, a total of 5 days; 60mg/M ~ 2, the first 4 and 5 days. The second course of treatment uses the original induction relief program. Maintenance therapy is no longer performed after consolidation. In the transplantation group of 23 cases,