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近十年来,顺铂作为抗癌新药引起人们的重视,本文报道顺铂治疗胃癌的研究.病例选择 22例经组织学确定并分型的进展性胃癌患者,16例接受过其它化疗。此次治疗与以往化疗的间隔时间至少在4周以上,病例年龄要求≤75岁,预计存活期>4周及肾功能试验正常者。治疗方法治疗前,患者先进行全身、盆腔与肛门检查、胸透、腹部超声、上消化道 x 线、听力图,铬-依地酸(EDTA)肾清除率及血液检查。血检包括:血清肌酐、血清癌胚抗原、血清谷-草转氨酶、血清碱性磷酸酶、血红蛋白、血小板和白细胞计数。除超声和上腹部 X 线检查每隔2次治疗复查一次外,余项检查均于每次治疗前重复一次.
In the past ten years, cisplatin has attracted people’s attention as a new anti-cancer drug. This article reports the study of cisplatin in the treatment of gastric cancer. Twenty-two patients with advanced gastric cancer that were identified and classified by histology were selected and 16 patients received other chemotherapy. The interval between this treatment and previous chemotherapy was at least 4 weeks. The age requirement of the case was ≤75 years, and the survival period was expected to be >4 weeks and the normal renal function test was performed. Treatment Methods Before treatment, patients first performed whole body, pelvic and anal examinations, chest thoracolumbar, abdominal ultrasound, upper gastrointestinal x-ray, audiogram, chromium-edetic acid (EDTA) renal clearance and blood tests. Blood tests included serum creatinine, serum carcinoembryonic antigen, serum trough-aspartate aminotransferase, serum alkaline phosphatase, hemoglobin, platelet, and white blood cell counts. Except for ultrasound and X-ray examination of the upper abdomen, the examinations were repeated every 2 treatments. The remaining examinations were repeated once before each treatment.