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目的:探讨蜂胶治疗小儿口腔溃疡新剂型的可行性。方法:对蜂胶超细微粉末经小分子纳米水凝胶设计进行了初步研究,试验中采用溶胶-凝胶法实现核黄素与三嗪环衍生物的二组分小分子纳米水凝胶基质对蜂胶超细微粉末的承载,自组装设计出蜂胶小分子纳米水凝胶,并在扫描电子显微镜进行观察。结果:探索出核黄素与三嗪环衍生物以摩尔比率配比为1∶2(c=0.11 mol/L)的凝胶基质具有最大载药量,承载蜂胶超细微粉末量最大为0.45 mg,且载药后小分子纳米水凝胶结构更加稳定;测定蜂胶小分子纳米水凝胶p H值在6.7~7.0之间,在p H 7~8的溶液中均较稳定,在0~55℃条件下稳定,对光稳定。结论:通过对蜂胶超分子纳米水凝胶的超分子凝胶设计的成功,预计能实现蜂胶新剂型的研发。
Objective: To investigate the feasibility of propolis in the treatment of new oral ulcer in children. Methods: A preliminary study was conducted on the design of ultra-fine propolis powder by means of a small molecule nano-hydrogel. Two-component small molecule nano-hydrogel matrix pairs of riboflavin and triazine ring derivatives were obtained by sol-gel method Propolis superfine powder bearing, self-assembly design of propolis small molecule nano-hydrogel, and observed by scanning electron microscopy. Results: The gel matrix with the molar ratio of riboflavin to triazine ring of 1: 2 (c = 0.11 mol / L) was found to have the highest drug loading. The maximum volume of propolis superfine powder was 0.45 mg , And the structure of the small molecule nano-hydrogel was more stable after drug loading. The p H value of the small molecule nano-hydrogel was between 6.7 and 7.0, and was stable in pH 7-8 solution. ℃ under the conditions of stability, light stability. Conclusion: The successful development of supramolecular gel design for propolis supramolecular nano hydrogel is expected to lead to the development of a new formulation of propolis.