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本文对我国胃癌高、低发区进展期胃癌(AGC)的临床和病理特点进行了观察,结果表明:①患者多为老年,男多于女(3∶1),病程短,多在2年内,症状多不典型;②癌多位于胃窦小弯,溃疡底部四层结构不典型,其中坏死层最显,瘢痕少,常有肌残留和癌浸润,组织类型以低分化腺癌和管状腺癌多见,癌细胞可显示不同程度异质性,越向深部浸润时可出现分化越低的倾向;③癌旁胃粘膜伴发病变的检出率及其程度均明显高于和重于同例非癌旁相应病变(P<0.005),提示前者与胃癌的发病关系更密切;④粘液组化染色证实肠型胃癌多见(P<0.005)。
This article has observed the clinical and pathological features of advanced gastric cancer (AGC) in high and low incidence areas of gastric cancer in China. The results show that: 1 The patients are mostly elderly, male is more than female (3:1), the disease course is short, mostly in 2 years Symptoms are more typical; 2 cancers are located in the small antrum of the gastric antrum, and the bottom four layers of the ulcer are not typical, in which the necrotic layer is most prominent, scars are few, often muscle residues and cancer infiltration, tissue types are poorly differentiated adenocarcinoma and tubular glands. More common cancers, cancer cells can show varying degrees of heterogeneity, the more infiltration into the deeper the tendency of the lower the tendency to appear; 3 the incidence and extent of the adjacent gastric cancer associated lesions were significantly higher than and greater than the same Cases of non-cancerous lesions (P<0.005) suggested that the former had a closer relationship with the incidence of gastric cancer; 4 Mucin histochemical staining confirmed intestinal type gastric cancer was more common (P<0.005).