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10例无并发症的高血压病患者于口服国产硝苯吡啶10 mg 3次/d 后第3 d 及1周检测血压及应用超声心动图检测左心功能。血压由21.5±3.4/12.4±1.4 kPa(161.4±25.9/92.8±10.8 mmHg)分别降至18.7±1.6/11.3±1.2 kPa(139.8±11.8/84.6±9.4 mmHg)、17.9±1.7/11.3±1.2 kPa(134.2±12.7/84.6±8.7 mmHg)(P 均<0.01);平均动脉压由15.2±0.9 kPa(114.2±7.7 mmHg)分别降至13.9±0.9 kPa(104.2±7.3 mmHg)、13.6±0.8 kPa(102.0±6.3 mmHg)(P 均<0.01),总外周阻力由1741.0±392.5 dyn·s/cm~5分别降至1514.0±175.5(P>0.05)及1263.1±237.6 dyn·s/cm~5(P<0.01)。舒张早期流速积分由7.2±1.3分别增至8.4±2.6及8.7±2.1((P 均<0.05),舒张早期及心房收缩期峰值流速、心指数等指标亦有所改善。提示国产硝苯吡啶能有效持久降压并改善左心功能。
Ten patients with hypertension without complication were tested for blood pressure on the 3rd and 1st week after oral administration of nifedipine 10 mg / d and the left ventricular function was detected by echocardiography. Blood pressure decreased from 21.5 ± 3.4 / 12.4 ± 1.4 kPa (161.4 ± 25.9 / 92.8 ± 10.8 mmHg) to 18.7 ± 1.6 / 11.3 ± 1.2 kPa (139.8 ± 11.8 / 84.6 ± 9.4 mmHg), 17.9 ± 1.7 / 11.3 ± 1.2 kPa (134.2 ± 12.7 / 84.6 ± 8.7 mmHg) (P <0.01). Mean arterial pressure decreased from 15.2 ± 0.9 kPa (114.2 ± 7.7 mmHg) to 13.9 ± 0.9 kPa (104.2 ± 7.3 mmHg) and 13.6 ± 0.8 kPa The mean peripheral resistance decreased from 1741.0 ± 392.5 dyn · s / cm ~ 5 to 1514.0 ± 175.5 (P> 0.05) and 1263.1 ± 237.6 dyn · s / cm ~ 5 <0.01). The integral of early diastolic velocity increased from 7.2 ± 1.3 to 8.4 ± 2.6 and 8.7 ± 2.1 respectively (P <0.05), and the indexes of early diastole and atrial systolic peak velocity and cardiac index also improved, which indicated that nifedipine Effective and lasting antihypertensive and improve left ventricular function.