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目的研究分析人乳头瘤病毒(human papillomavirus,HPV)基因分型与宫颈组织病变的相关性。方法选取2008-09-2014-09华中科技大学附属武汉市普爱医院1 200例宫颈可疑性病变的宫颈组织标本进行HPV基因检测,并针对筛检阳性的病例标本的HPV-DNA进行测序确诊,最终的诊断依照组织病理学检查结果。结果选取的1 200例可疑宫颈病变的组织标本经过HPV基因检测后检测出HPV阳性病例414例,HPV阳性检出率为34.5%,然后经过组织病理学检测其中有220例确诊为不同程度的宫颈病变患者,本研究患者的病变率高达18.33%,其中HPV感染的病例有171例,其包括LSIL(低度鳞状上皮内病变)患者96例,其中有64例病例存在HPV感染。此外,HSIL(高度鳞状上皮内病变)患者有110例,其中有93例病例存在HPV感染,宫颈癌患者14例,HPV感染患者14例。结论研究表明,HPV基因分型对于宫颈癌的筛查及其防治均具有重要的临床价值。
Objective To study the relationship between genotyping of human papillomavirus (HPV) and cervical lesions. Methods The HPV gene was detected in cervical tissue specimens of 1 200 cases of cervical suspicious lesions attached to the Central Hospital of Huazhong University of Science and Technology on 2008-09-2014-09. The HPV-DNA of the positive specimens were sequenced, The final diagnosis is based on histopathological findings. Results A total of 1 200 cases of suspected cervical lesions were detected by HPV gene test in 414 cases of HPV-positive cases, the positive rate of HPV was 34.5%, and then through the pathological examination of 220 cases were diagnosed with varying degrees of cervical Lesions, the study patients with lesions rate as high as 18.33%, including HPV infection in 171 cases, including LSIL (low grade squamous intraepithelial lesions) in 96 patients, of which 64 cases of HPV infection. In addition, there were 110 HSIL patients with HPV infection in 93 cases, 14 cases of cervical cancer and 14 cases of HPV infection. Conclusion Studies have shown that HPV genotyping has important clinical value for the screening of cervical cancer and its prevention and treatment.