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目的研究妊娠期血浆D-二聚体水平与妊娠高血压综合征相关性。方法选取2015年2月-2016年2月在中山市三乡医院进行产前检查、分娩及产后随访的高血压综合征孕妇150例设为观察组选取同期体检的150例健康孕妇为对照组。对比两组孕妇血浆D-二聚体水平,同时观察组孕妇根据病情严重程度分为轻度组63例、中度组42例及重度组45例,分别比较3组血浆D-二聚体水平并作相关性分析。结果观察组孕妇D-二聚体水平为(876.3±44.5)ng/ml,显著高于对照组的(278.5±60.2)ng/ml差异有统计学意义(P<0.05)。轻度组的D-二聚体水平显著低于中度组与重度组,而中度组的D-二聚体水平又显著低于重度组(P<0.05)。经相关性分析可得血浆D-二聚体水平与妊娠高血压综合征严重程度呈显著正相关关系(r=0.781,P=0.000)。结论妊娠高血压综合征患者血浆D-二聚体水平显著升高且与病情严重程度呈显著正相关,D-二聚体检测具有应用价值。
Objective To study the relationship between plasma D-dimer levels and gestational hypertension in pregnancy. Methods A total of 150 pregnant women with hypertension syndrome who underwent antenatal examination, delivery and postpartum follow-up from February 2015 to February 2016 in Sanxiang Hospital of Zhongshan City were enrolled in the observation group. 150 healthy pregnant women were selected as the control group. The levels of plasma D-dimer in two groups of pregnant women were compared. At the same time, pregnant women in the observation group were divided into mild group (63 cases), moderate group (42 cases) and severe group (45 cases) according to the severity of the disease. Plasma D-dimer And make correlation analysis. Results The level of D-dimer in the observation group was (876.3 ± 44.5) ng / ml, which was significantly higher than that in the control group (278.5 ± 60.2) ng / ml (P <0.05). The level of D-dimer in mild group was significantly lower than that in moderate group and severe group, while the level of D-dimer in moderate group was significantly lower than that in severe group (P <0.05). Correlation analysis showed that there was a significant positive correlation between plasma D-dimer level and the severity of pregnancy-induced hypertension (r = 0.781, P = 0.000). Conclusion The plasma D-dimer level in patients with pregnancy induced hypertension syndrome is significantly increased and positively correlated with the severity of the disease. D-dimer test has the value of application.