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幽门螺杆菌 (Hp)抗原可保护小鼠免受猫螺杆菌 (Hf)感染的事实表明 ,这两种细菌有交叉保护抗原 ,业已证明脲酶 (Ure)是 Hf和 Hp的交叉保护分子。为了进一步确定交叉反应和交叉保护性抗原 ,作者用一临床分离株 (Hp92 1 0 2 3株 )作为 DNA供体在 λZAP表达载体中构建基因文库 ;同
The fact that Helicobacter pylori (Hp) antigens protect mice from H. catarrhalis (Hf) infection suggests that the two bacteria have cross-protected antigens and that urease (Ure) has been shown to cross-protect Hf and Hp. To further identify cross-reactive and cross-protective antigens, the authors used a clinical isolate (Hp921023) as a DNA donor to construct a gene library in lambda ZAP expression vector;