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β-内酰胺酶抑制剂和β-内酰胺类抗生素联合应用可有效的抑制产生β-内酰胺酶的耐药菌的活性。为了克服单一药物口服吸收较差以及在联合给药时两者在吸收速率、体内分布和有效作用时间等方面的差异,作者利用互为前体药物的原理将β-内酰胺酶抑制剂 CP-45899(Penicillanic acid sulfo-ne)分别与氨苄青霉素和氮(艹卓)脒青霉素(Me-cillinam)缩合成二个双酯化合物——VD1827和VD1825,它们被称为互为前体药
The combination of β-lactamase inhibitor and β-lactam antibiotic can effectively inhibit the activity of β-lactamase-producing drug-resistant bacteria. In order to overcome the poor oral absorption of a single drug as well as the difference in absorption rate, in vivo distribution and effective time between the two drugs when administered in combination, the authors used the principle of mutual prodrug to separate the β-lactamase inhibitor CP- 45899 (Penicillanic acid sulfo-ne) is condensed with ampicillin and Me-cillinam, respectively, into two di-ester compounds, VD1827 and VD1825, which are known as prodrugs