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酞丁安(3-Phthalimido-2-oxo-bu-fyraldehyde-bis-thiosemlcarbazone,V6133)是药物研究所设计合成的一种缩氨基硫脲类化合物。本实验室的工作表明,它对单纯疱疹病毒Ⅰ型与Ⅱ型(HSV-1与HSV-2)的复制有明显的抑制作用,并且发现,最高可溶解剂量的酞丁安(100μg/ml)对HSV-2DNA聚合酶试管内转录活性没有明
3-Phthalimido-2-oxo-bu-fyraldehyde-bis-thiosemlcarbazone (V6133) is a kind of thiosemicarbazone compound designed and synthesized by Institute of Materia Medica. Our laboratory work showed that it has a significant inhibitory effect on the replication of herpes simplex virus type 1 and type 2 (HSV-1 and HSV-2), and found that the highest soluble dose of thalidomide (100 μg / ml) In vitro transcriptional activity of HSV-2 DNA polymerase is not known