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目的:探讨氢化泼尼松(PNS)和谷胱甘肽(GSH)在乳腺癌蒽环类化疗中对化疗毒副反应的作用。方法:接受蒽环类化疗的乳腺癌患者102例,随机分为治疗组52例和对照组50例。治疗组在常规止吐药(5-HT3受体拮抗剂-托烷司琼)的基础上予PNS和GSH静脉注射;对照组仅予止吐(5-HT3受体拮抗剂-托烷司琼)处置。观察两组患者消化道反应、骨髓抑制、心脏毒性及肝功能损害等情况。结果:在化疗中应用PNS和GSH,治疗组恶心呕吐和肝脏丙氨酸氨基转移酶(ALT)升高的发生率均显著低于对照组(P=0.03,P=0.001)。在白细胞减少和心电图改变方面,两组间数据比较差异无统计学意义,P>0.05。结论:PNS和GSH在乳腺癌蒽环类化疗中能有效地减轻化疗过程中恶心呕吐的程度、控制肝脏ALT的升高。
Objective: To investigate the effects of prednisolone (PNS) and glutathione (GSH) on the side effects of chemotherapy in anthracycline-induced breast cancer. Methods: 102 cases of breast cancer patients receiving anthracycline chemotherapy were randomly divided into treatment group (52 cases) and control group (50 cases). The treatment group received intravenous injection of PNS and GSH on the basis of a conventional antiemetic drug (5-HT3 receptor antagonist-tropisetron); the control group received only antiemetic (5-HT3 receptor antagonist-tropisetron ) Disposal. The two groups of patients were observed gastrointestinal reactions, bone marrow suppression, cardiac toxicity and liver damage and so on. Results: The incidence of nausea and vomiting and hepatic ALT in the treatment group was significantly lower than that in the control group (P = 0.03, P = 0.001). In the leukopenia and ECG changes, the data between the two groups showed no significant difference (P> 0.05). Conclusion: PNS and GSH can effectively reduce the degree of nausea and vomiting during chemotherapy and control the increase of liver ALT in breast cancer anthracycline chemotherapy.