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本文旨在探讨川芎嗪（TMP）抗离体大鼠心脏缺氧／复氧再灌注心律失常的作用及机制。结果表明氧反常组在再灌初期均发生心律失常，持续至2．8±2．2min；川芎嗪组心律失常发生率仅为28％．平均持续时间为3．5±1．5min．两组有显著性差异（p<0．01）。其作用机理可能与TMP清除自由基，抗脂质过氧化而维持细胞正常电活动和阻断Ca2+内流有关。研究提示TMP是优于异搏定的Ca2+通道阻断剂。
This article aims to investigate the effects and mechanisms of tetramethylpyrazine (TMP) against cardiac arrhythmia induced by hypoxia/reoxygenation/reperfusion in isolated hearts. The results showed that arrhythmia occurred in the oxygen abnormal group at the early stage of reperfusion and lasted to 2.8±2.2 minutes; the incidence of arrhythmia in the ligustrazine group was only 28%. The average duration is 3.5±1.5min. There was a significant difference between the two groups (p<0.01). Its mechanism of action may be related to TMP scavenging free radicals, anti-lipid peroxidation while maintaining normal cell electrical activity and blocking Ca 2+ influx. Studies suggest that TMP is superior to verapamil in Ca2+ channel blockers.