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几项研究已经显示维生素缺乏与神经管缺损(NTD)有关,补充维生素可预防NTD。由于试验设计和方法学的缺陷,对在一些高危孕妇进行的这些观察结果的正确性还有些争论。Smithells等人测定了900个孕早期妇女的红细胞叶酸水平,发现出生NTD孩子的
Several studies have shown that vitamin deficiencies are associated with neural tube defects (NTDs) and vitamin supplements prevent NTD. Due to experimental design and methodological flaws, there is some debate as to the validity of these observations in some high-risk pregnancies. Smithells et al. Determined erythrocyte folic acid levels in 900 pregnant women in early pregnancy and found that children born with NTD