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目的对东莞市甲型H1N1流感疫苗接种不良反应的发生情况进行分析,为免疫策略的制定提供依据。方法从《儿童预防接种信息管理系统》中收集东莞市的不良反应个案信息,收集疑似异常反应病例的个案调查表以及东莞市各接种点每天报告的《广东省东莞市甲型H1N1流感疫苗接种相关信息日报表》等资料,使用Excel2003对数据进行描述性流行病学分析,用SPSS13.0进行卡方检验。结果自2009年11月3日-2010年2月28日,东莞市甲流疫苗接种累计不良反应发生率为4.72/万,病例在不同性别及不同年龄组间的不良反应发生情况差异无统计学意义,医务人员的不良反应发生率明显高于其他职业人员,而流动人口的不良反应发生率要明显低于其他职业,病例大多数为一般反应,多为48 h内出现症状,并以发热为主要表现,通过被动监测方式发现为主。结论东莞市甲流疫苗接种后产生的不良反应以轻症为主,接种安全性较高。今后应该在疫苗接种工作中,加强对市民进行疫苗接种不良反应的宣传,特别是对流动人口进行疫苗接种不良反应的识别、处理和及时就诊方面的宣传。另外,主动监测工作有待进一步加强,以便更好的掌握受种者,特别是主动就医趋势较差的流动人口受种者的不良反应发生情况。
Objective To analyze the incidence of adverse reactions of influenza A (H1N1) vaccination in Dongguan and provide the basis for the formulation of immunization strategies. Methods The data of adverse drug reactions in Dongguan were collected from the “Childhood Vaccination Information Management System” to collect the case-studies of suspected anomalous cases and the reports of “H1N1 influenza vaccination in Dongguan, Guangdong Province” Information Daily Report "and other data, the use of Excel2003 descriptive epidemiological analysis of data, using SPSS13.0 for chi-square test. Results From November 3, 2009 to February 28, 2010, the cumulative incidence of adverse reactions in A flu vaccination in Dongguan was 4.72 / million. There was no statistical difference in the incidence of adverse reactions among different sexes and different age groups Significance, the incidence of adverse reactions of medical staff was significantly higher than other occupational personnel, and the incidence of adverse reactions in floating population was significantly lower than other occupations, the majority of cases were general reactions, mostly within 48 h symptoms, and fever The main performance, found mainly by passive monitoring. Conclusion Anemia caused by A flu vaccine in Dongguan City was mainly mild and safe in vaccination. In the future, we should step up publicity on public vaccination adverse reactions during vaccination work, especially on the identification, handling and timely treatment of vaccination side-effects among floating population. In addition, active surveillance needs to be further strengthened in order to better understand the adverse reactions of those who breed, especially migrants who are less likely to take the initiative to seek medical treatment.