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目的探讨肿瘤患者意外抗体的分布情况和影响因素。方法用微柱凝集技术对本院2011年1月-2015年10月48 369例肿瘤患者标本进行抗体筛查实验,阳性结果依据2010版AABB抗体鉴定指南进行抗体鉴定,分析肿瘤患者意外抗体分布特点。结果 255例患者意外抗体阳性,阳性率0.53%;意外抗体以抗-M(57/22.35%)、抗-Lea(54/21.18%)及抗-E(53/20.78%)居多。多因素Logistic回归分析显示患者结直肠肿瘤、淋巴瘤、是否转移、输血史、性别、怀孕次数、及Rh D血型对意外抗体产生有影响(OR=1.811、2.782、3.484、1.994、1.462、1.667、2.999,均为P<0.05)。结论肿瘤患者的意外抗体产生与疾病、输血史、性别等多种因素有关;根据抗体分布特点定期筛查部分库存血的Rh、MNS等血型系统抗原,能够快速满足肿瘤患者用血需求,保证临床输血治疗的安全与有效。
Objective To investigate the distribution and influential factors of unexpected antibodies in cancer patients. Methods The micro-column agglutination technique was used to screen 48 369 tumor samples from January 2011 to October 2015 in our hospital. The positive results were identified according to the 2010 AABB antibody identification guidelines, and the distribution of the unexpected antibody in tumor patients was analyzed . Results A total of 255 patients were found to have unintended antibody positive rate of 0.53%. Most of the unintended antibodies were anti-M (57 / 22.35%), anti-Lea (54 / 21.18%) and anti-E (53 / 20.78%). Multivariate Logistic regression analysis showed that colorectal cancer, lymphoma, metastasis, blood transfusion history, gender, number of pregnancies and Rh D blood type had an influence on unexpected antibody production (OR = 1.811,2.782,3.484,1.994,1.462,1.667, 2.999, all P <0.05). Conclusions The occurrence of unexpected antibodies in cancer patients is related to various factors such as disease, blood transfusion history and gender. Regular screening of blood group antigen such as Rh and MNS based on antibody distribution can rapidly meet the blood requirement of cancer patients and ensure clinical Transfusion therapy is safe and effective.