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目的:观察尼可地尔治疗不稳定型心绞痛的临床疗效。方法:选择不稳定型心绞痛125例,随机分为观察组63例和对照组62例,均给予常规抗心绞痛治疗,观察组在此基础上加用尼可地尔治疗,对照组给予安慰剂。疗程均为2个月,比较两组临床疗效和治疗后1周、2周、8周患者心绞痛发作时心电图ST段压低改善情况。结果:观察组总有效率显著高于对照组(P<0.05);治疗后,两组心绞痛发作时ST段压低情况均显著少于治疗前,观察组ST段压低改善情况显著优于同期对照组(P<0.05)。结论:加用尼可地尔治疗不稳定型心绞痛效果优于常规治疗。
Objective: To observe the clinical effect of nicorandil in the treatment of unstable angina pectoris. Methods: A total of 125 patients with unstable angina pectoris were randomly divided into observation group (n = 63) and control group (n = 62). All patients were given conventional anti - angina pectoris. Nicorandil was used in the observation group and placebo in the control group. The course of treatment was 2 months. The improvement of ECG ST segment depression was compared between the two groups in clinical curative effect and 1 week, 2 weeks and 8 weeks after treatment. Results: The total effective rate in the observation group was significantly higher than that in the control group (P <0.05). After the treatment, the depression of ST segment in both groups was significantly less than that before treatment, and the improvement of ST depression in the observation group was significantly better than that in the control group (P <0.05). Conclusion: The effect of nicorandil on unstable angina pectoris is better than that of routine treatment.